Medical Assistant Salary in St. Louis, MO — 2026 Guide
Estimated salaries are adjusted for St. Louis's cost of living (index: 86). National data from BLS OEWS 2024; city adjustments reflect local market conditions.
Medical Assistant Salary in St. Louis — Key Numbers
Cost of Living in St. Louis
Rent-to-income below 28% is considered affordable; above 35% is cost-burdened. Home price multiple below 3× is affordable; above 5× is expensive by traditional guidelines.
Job Market in St. Louis
St. Louis has a metro population of 2,820,000, offering a large, diverse job market with many employers across all industries. The 4.3% unemployment rate is near the national average.
Financial Calculators for St. Louis
Other Professions in St. Louis
Medical Assistant Salary — Other Missouri Cities
Frequently Asked Questions
How much does a Medical Assistant make in St. Louis, MO?
The estimated median salary for a Medical Assistant in St. Louis is $36,120 per year (2026). This is derived from the national BLS median of $42,000 adjusted by St. Louis's cost of living index (86). The typical salary range runs from $30,926 (25th percentile) to $42,630 (75th percentile), with top earners reaching $49,742.
Is St. Louis affordable for a Medical Assistant?
On a $36,120 annual salary, a Medical Assistant in St. Louis would spend approximately 29.9% of gross monthly income on median rent ($900/month). This is approaching the 30–35% cost-burden threshold; careful budgeting is recommended. The median home price of $205,000 is 5.7× the annual salary.
How does a Medical Assistant's salary compare to St. Louis's overall income?
St. Louis's median household income is $61,400. A Medical Assistant earning the city-adjusted median of $36,120 earns 41.2% less than the typical St. Louis household income. This may reflect that the profession is entry-level or that St. Louis has a particularly high median household income due to high-earning industries.
Explore More Salary Data
Salary data from U.S. Bureau of Labor Statistics (BLS) OEWS, 2024 release. City salary estimates adjusted by cost of living index. City data from Census Bureau, BLS, Zillow, and ApartmentAdvisor (2024–2025). Last updated: March 2026.