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Cost of Living: San Diego, CA vs St. Louis, MO

Wondering how far your dollar stretches in San Diego compared to St. Louis? Below we break down housing costs, rent, taxes, income, and quality of life using 2026 data so you can make an informed relocation or remote-work decision. Every number is computed from Census, BLS, and Zillow data specific to these two metro areas.

TL;DR

San Diego cost-of-living index is 163 vs 86 for St. Louis (US = 100). Median home: $875,000 vs $205,000. Median rent: $2,195/mo vs $900/mo.

Source: Census ACS · Zillow ZHVI/ZORI · BEA RPP, 2026

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St. Louis is 47.2% cheaper than San Diego
COL Index: San Diego 163 vs St. Louis 86 (national avg = 100)
Written by Jere Salmisto, Founder & Quantitative Systems Builder, CalcFi·Reviewed by CalcFi Editorial·Last reviewed 2026-04-19

San Diego vs St. Louis — At a Glance

San DiegoMetricSt. LouisDifference
163Cost of Living Index86-47.2%
$875,000Median Home Price$205,000-76.6%
$2,195Median Monthly Rent$900-59.0%
$91,000Median Household Income$61,400-32.5%
0.7%Property Tax Rate1.0%+38.9%
3.8%Unemployment Rate4.3%+13.2%
27 minAverage Commute24 min-11.1%
36.1Median Age36.6+1.4%
3,340,000Metro Population2,820,000-15.6%

Data sourced from Census Bureau, BLS, Zillow, and ApartmentAdvisor (2024-2025). COL Index: 100 = national average.

Housing Comparison: San Diego vs St. Louis

Monthly mortgage assumes 6.5% interest, 30-year fixed, 20.0%down payment. PITI includes principal, interest, property tax, and homeowner's insurance.

San Diego

Median Home Price$875,000
Down Payment (20.0%)$175,000
Loan Amount$700,000
Principal & Interest$4,424/mo
Property Tax$525/mo
Insurance$255/mo
Monthly PITI$5,205/mo

St. Louis

Median Home Price$205,000
Down Payment (20.0%)$41,000
Loan Amount$164,000
Principal & Interest$1,037/mo
Property Tax$171/mo
Insurance$60/mo
Monthly PITI$1,267/mo

Rent & Affordability Ratios

Median Monthly Rent$2,195 vs $900 (-$1,295/mo)
Annual Rent Difference$15,540/yr more in San Diego
Home Price-to-Income Ratio9.6x (San Diego) vs 3.3x (St. Louis)
Years to Save 20% Down (15% savings rate)12.8 yrs (San Diego) vs 4.5 yrs (St. Louis)

Buying a home in San Diego costs $5,205/month (PITI) compared to $1,267/month in St. Louis — a difference of $3,938/month or $47,256/year. The price-to-income ratio is 9.6x in San Diego versus 3.3x in St. Louis, suggesting St. Louis is relatively more affordable for homebuyers relative to local incomes. At a 15% savings rate, it takes 12.8 years to save a down payment in San Diego compared to 4.5 years in St. Louis.

Tax Comparison: San Diego vs St. Louis

Estimated on each city's median household income, single filer, standard deduction, 2025 rates.

Tax CategorySan DiegoSt. Louis
Gross Income$91,000$61,400
State Income Tax$4,490$2,005
Federal Income Tax$11,469$5,239
FICA (SS + Medicare)$6,962$4,697
Property Tax (on median home)$6,300/yr$2,050/yr
State Sales Tax Rate7.2%4.2%
Total Tax Burden$22,921 (25.2%)$11,941 (19.4%)
Take-Home Pay$68,079$49,459

On median household income, total taxes (federal + state + FICA) come to $22,921 in San Diego (25.2% effective) versus $11,941 in St. Louis (19.4% effective). After taxes, take-home pay is $68,079 in San Diego and $49,459 in St. Louis. Property taxes add $6,300/year on the median San Diego home versus $2,050/year in St. Louis.

Salary Equivalence: What Your Income Is Worth

A $91,000 salary in San Diego equals
$48,012
in St. Louis
A $61,400 salary in St. Louis equals
$116,374
in San Diego

These figures adjust for cost of living using the formula: adjusted = salary × (COL_destination / COL_origin). If you earn $91,000 in San Diego (COL 163) and relocate to St. Louis (COL 86), you would need $48,012 to maintain the same purchasing power. This means you can take a pay cut of $42,988 and still maintain your lifestyle in St. Louis.

Quality of Life: San Diego vs St. Louis

Average Commute
27 min
San Diego
24 min
St. Louis
3 min longer in San Diego
Unemployment Rate
3.8%
San Diego
4.3%
St. Louis
San Diego lower
Metro Population
3.3M
San Diego
2.8M
St. Louis
San Diego is 1.2x larger

Beyond costs, quality of life matters. The average commute in San Diego is 27 minutes versus 24 minutes in St. Louis, a difference of 3 minutes each way. San Diego's lower unemployment rate of 3.8% versus 4.3% suggests a stronger job market. St. Louis skews slightly older with a median age of 36.6 vs 36.1 in San Diego.

Other Cost of Living Comparisons

New York vs San DiegoCOL 187 vs 163Los Angeles vs San DiegoCOL 173 vs 163Chicago vs San DiegoCOL 114 vs 163New York vs St. LouisCOL 187 vs 86Los Angeles vs St. LouisCOL 173 vs 86Chicago vs St. LouisCOL 114 vs 86

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Frequently Asked Questions

Is San Diego or St. Louis more expensive?

San Diego is 47.2% more expensive than St. Louis overall. San Diego has a cost of living index of 163 compared to 86 for St. Louis (national average = 100). The biggest difference is housing: the median home costs $875,000 in San Diego vs $205,000 in St. Louis.

How much more does housing cost in San Diego vs St. Louis?

The median home price in San Diego is $875,000, which is $670,000 more than St. Louis's median of $205,000. Monthly rent follows a similar pattern: $2,195/month in San Diego vs $900/month in St. Louis, a difference of $1,295/month or $15,540/year.

What salary do I need in St. Louis to match my San Diego income?

To maintain the same standard of living, a $91,000 salary in San Diego is equivalent to $48,012 in St. Louis. This is based on the cost of living index ratio: San Diego's COL index of 163 vs St. Louis's 86. Conversely, $61,400 in St. Louis equals $116,374 in San Diego.

Which city has lower taxes, San Diego or St. Louis?

On a median household income, the combined federal, state, and FICA tax burden is $22,921 (25.2% effective rate) in San Diego vs $11,941 (19.4% effective rate) in St. Louis. Property taxes on the median home are $6,300/year in San Diego (0.7% rate) vs $2,050/year in St. Louis (1.0% rate). Sales tax rates are 7.2% in California and 4.2% in Missouri.

What is the median household income in San Diego and St. Louis?

San Diego median household income: $91,000/yr. St. Louis median household income: $61,400/yr (Census ACS).

How does rent compare in San Diego vs St. Louis?

Median monthly rent: $2,195 in San Diego vs $900 in St. Louis. Annualized that is $26,340 vs $10,800.

Which city is better for remote workers, San Diego or St. Louis?

St. Louis offers a lower cost of living (index 86 vs 163), which lets remote-workers keeping a coastal salary stretch further. San Diego typically wins on amenities and labor-market depth.

Where does the data on this comparison come from?

San Diego and St. Louis numbers are pulled from Zillow ZHVI/ZORI (home values, rent), the U.S. Census Bureau ACS (income, demographics), and BEA RPP (cost-of-living index). Each value is timestamped on the page.

How often is this San Diego vs St. Louis comparison updated?

Source feeds (Zillow, Freddie Mac PMMS, Census ACS, BEA RPP) are refreshed on their native cadence. Page caches revalidate every 24 hours via Next.js ISR.

Does this comparison replace tax or financial advice?

No. The San Diego vs St. Louis cost-of-living page is educational reference using public data and standard formulas. It is not personalized tax, legal, or investment advice. Consult a licensed professional for material decisions.

Explore More

All City ComparisonsSan Diego COL CalculatorSt. Louis COL CalculatorSalary GuidesMortgage Affordability CalculatorRent vs Buy Calculator

Sources & Citations

  1. Zillow Research — ZHVI (home values) & ZORI (observed rent index) — zillow.com/research/data
  2. U.S. Census Bureau — American Community Survey (ACS) 5-year estimates — census.gov/acs
  3. Bureau of Economic Analysis — Regional Price Parities by state and MSA — bea.gov/rpp
  4. Tax Foundation — effective state and local tax rates — taxfoundation.org
  5. Freddie Mac PMMS — weekly national average mortgage rates — freddiemac.com/pmms
  6. Internal Revenue Service — federal income tax brackets and standard deduction — irs.gov
  7. U.S. Bureau of Labor Statistics — unemployment and wage statistics — bls.gov
Methodology & Assumptions

Home prices use Zillow Home Value Index (ZHVI)[1]; rents use Zillow Observed Rent Index (ZORI)[1]. Median household income comes from the Census ACS 5-year estimates[2].

COL indices use the BEA Regional Price Parity methodology[3], normalized so 100 = national average.

Property tax rates are effective rates from the Tax Foundation[4], expressed as % of owner-occupied home value. Mortgage estimates assume 6.5% fixed rate[5], 30-year term, 20.0% down, $1,800/yr homeowners insurance.

Federal tax calculations[6] assume single filer, standard deduction. State tax uses the top marginal rate times taxable income after the state standard deduction. FICA = 6.2% Social Security (up to wage base) + 1.45% Medicare.

Salary equivalence uses adjusted = salary × (COL_destination / COL_origin). This captures cost-of-living shift but not state income tax differences.

Unemployment figures are the most recent monthly MSA-level readings from the BLS LAUS series[7].

Last reviewed is computed from the maximum retrievedAt across every source this page consumes.

City data from Census Bureau[2], BLS[7], and Zillow[1] (2024-2025). Tax calculations use 2025 IRS rates[6], single filer, standard deduction. Mortgage estimates assume 6.5% PMMS rate[5], 30-year term, 20.0% down. COL Index: 100 = national average[3]. Last reviewed 2026-04-19.