Medical Assistant Salary in Greenville, SC — 2026 Guide
Estimated salaries are adjusted for Greenville's cost of living (index: 96). National data from BLS OEWS 2024; city adjustments reflect local market conditions.
Medical Assistant Salary in Greenville — Key Numbers
Cost of Living in Greenville
Rent-to-income below 28% is considered affordable; above 35% is cost-burdened. Home price multiple below 3× is affordable; above 5× is expensive by traditional guidelines.
Job Market in Greenville
Greenville has a metro population of 960,000, offering a sizeable job market with strong opportunities across key sectors. The 3.2% unemployment rate is below the national average, suggesting a tight labor market favorable to job seekers.
Financial Calculators for Greenville
Other Professions in Greenville
Medical Assistant Salary — Other South Carolina Cities
Frequently Asked Questions
How much does a Medical Assistant make in Greenville, SC?
The estimated median salary for a Medical Assistant in Greenville is $40,320 per year (2026). This is derived from the national BLS median of $42,000 adjusted by Greenville's cost of living index (96). The typical salary range runs from $34,522 (25th percentile) to $47,587 (75th percentile), with top earners reaching $55,526.
Is Greenville affordable for a Medical Assistant?
On a $40,320 annual salary, a Medical Assistant in Greenville would spend approximately 38.7% of gross monthly income on median rent ($1,300/month). This exceeds the 35% cost-burden threshold. Many Medical Assistants in Greenville may find housing costs a significant financial pressure. The median home price of $295,000 is 7.3× the annual salary.
How does a Medical Assistant's salary compare to Greenville's overall income?
Greenville's median household income is $64,400. A Medical Assistant earning the city-adjusted median of $40,320 earns 37.4% less than the typical Greenville household income. This may reflect that the profession is entry-level or that Greenville has a particularly high median household income due to high-earning industries.
Explore More Salary Data
Salary data from U.S. Bureau of Labor Statistics (BLS) OEWS, 2024 release. City salary estimates adjusted by cost of living index. City data from Census Bureau, BLS, Zillow, and ApartmentAdvisor (2024–2025). Last updated: March 2026.