Registered Nurse Salary in Greenville, SC — 2026 Guide
Estimated salaries are adjusted for Greenville's cost of living (index: 96). National data from BLS OEWS 2024; city adjustments reflect local market conditions.
Registered Nurse Salary in Greenville — Key Numbers
Cost of Living in Greenville
Rent-to-income below 28% is considered affordable; above 35% is cost-burdened. Home price multiple below 3× is affordable; above 5× is expensive by traditional guidelines.
Job Market in Greenville
Greenville has a metro population of 960,000, offering a sizeable job market with strong opportunities across key sectors. The 3.2% unemployment rate is below the national average, suggesting a tight labor market favorable to job seekers.
Financial Calculators for Greenville
Other Professions in Greenville
Registered Nurse Salary — Other South Carolina Cities
Frequently Asked Questions
How much does a Registered Nurse make in Greenville, SC?
The estimated median salary for a Registered Nurse in Greenville is $82,627 per year (2026). This is derived from the national BLS median of $86,070 adjusted by Greenville's cost of living index (96). The typical salary range runs from $66,134 (25th percentile) to $103,382 (75th percentile), with top earners reaching $127,373.
Is Greenville affordable for a Registered Nurse?
On a $82,627 annual salary, a Registered Nurse in Greenville would spend approximately 18.9% of gross monthly income on median rent ($1,300/month). This is well within the 28% affordability threshold, making Greenville relatively affordable for this profession. The median home price of $295,000 is 3.6× the annual salary.
How does a Registered Nurse's salary compare to Greenville's overall income?
Greenville's median household income is $64,400. A Registered Nurse earning the city-adjusted median of $82,627 earns 28.3% more than the typical Greenville household — placing them solidly in the middle-to-upper income tier for the city.
Explore More Salary Data
Salary data from U.S. Bureau of Labor Statistics (BLS) OEWS, 2024 release. City salary estimates adjusted by cost of living index. City data from Census Bureau, BLS, Zillow, and ApartmentAdvisor (2024–2025). Last updated: March 2026.