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Cost of Living: San Francisco, CA vs St. Louis, MO

Wondering how far your dollar stretches in San Francisco compared to St. Louis? Below we break down housing costs, rent, taxes, income, and quality of life using 2026 data so you can make an informed relocation or remote-work decision. Every number is computed from Census, BLS, and Zillow data specific to these two metro areas.

TL;DR

San Francisco cost-of-living index is 214 vs 86 for St. Louis (US = 100). Median home: $1,350,000 vs $205,000. Median rent: $3,498/mo vs $900/mo.

Source: Census ACS · Zillow ZHVI/ZORI · BEA RPP, 2026

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St. Louis is 59.8% cheaper than San Francisco
COL Index: San Francisco 214 vs St. Louis 86 (national avg = 100)
Written by Jere Salmisto, Founder & Quantitative Systems Builder, CalcFi·Reviewed by CalcFi Editorial·Last reviewed 2026-04-19

San Francisco vs St. Louis — At a Glance

San FranciscoMetricSt. LouisDifference
214Cost of Living Index86-59.8%
$1,350,000Median Home Price$205,000-84.8%
$3,498Median Monthly Rent$900-74.3%
$131,000Median Household Income$61,400-53.1%
0.6%Property Tax Rate1.0%+58.7%
3.8%Unemployment Rate4.3%+13.2%
34 minAverage Commute24 min-29.4%
38.3Median Age36.6-4.4%
4,740,000Metro Population2,820,000-40.5%

Data sourced from Census Bureau, BLS, Zillow, and ApartmentAdvisor (2024-2025). COL Index: 100 = national average.

Housing Comparison: San Francisco vs St. Louis

Monthly mortgage assumes 6.5% interest, 30-year fixed, 20.0%down payment. PITI includes principal, interest, property tax, and homeowner's insurance.

San Francisco

Median Home Price$1,350,000
Down Payment (20.0%)$270,000
Loan Amount$1,080,000
Principal & Interest$6,826/mo
Property Tax$709/mo
Insurance$394/mo
Monthly PITI$7,929/mo

St. Louis

Median Home Price$205,000
Down Payment (20.0%)$41,000
Loan Amount$164,000
Principal & Interest$1,037/mo
Property Tax$171/mo
Insurance$60/mo
Monthly PITI$1,267/mo

Rent & Affordability Ratios

Median Monthly Rent$3,498 vs $900 (-$2,598/mo)
Annual Rent Difference$31,176/yr more in San Francisco
Home Price-to-Income Ratio10.3x (San Francisco) vs 3.3x (St. Louis)
Years to Save 20% Down (15% savings rate)13.7 yrs (San Francisco) vs 4.5 yrs (St. Louis)

Buying a home in San Francisco costs $7,929/month (PITI) compared to $1,267/month in St. Louis — a difference of $6,662/month or $79,944/year. The price-to-income ratio is 10.3x in San Francisco versus 3.3x in St. Louis, suggesting St. Louis is relatively more affordable for homebuyers relative to local incomes. At a 15% savings rate, it takes 13.7 years to save a down payment in San Francisco compared to 4.5 years in St. Louis.

Tax Comparison: San Francisco vs St. Louis

Estimated on each city's median household income, single filer, standard deduction, 2025 rates.

Tax CategorySan FranciscoSt. Louis
Gross Income$131,000$61,400
State Income Tax$8,210$2,005
Federal Income Tax$20,506$5,239
FICA (SS + Medicare)$10,022$4,697
Property Tax (on median home)$8,505/yr$2,050/yr
State Sales Tax Rate7.2%4.2%
Total Tax Burden$38,738 (29.6%)$11,941 (19.4%)
Take-Home Pay$92,262$49,459

On median household income, total taxes (federal + state + FICA) come to $38,738 in San Francisco (29.6% effective) versus $11,941 in St. Louis (19.4% effective). After taxes, take-home pay is $92,262 in San Francisco and $49,459 in St. Louis. Property taxes add $8,505/year on the median San Francisco home versus $2,050/year in St. Louis.

Salary Equivalence: What Your Income Is Worth

A $131,000 salary in San Francisco equals
$52,645
in St. Louis
A $61,400 salary in St. Louis equals
$152,786
in San Francisco

These figures adjust for cost of living using the formula: adjusted = salary × (COL_destination / COL_origin). If you earn $131,000 in San Francisco (COL 214) and relocate to St. Louis (COL 86), you would need $52,645 to maintain the same purchasing power. This means you can take a pay cut of $78,355 and still maintain your lifestyle in St. Louis.

Quality of Life: San Francisco vs St. Louis

Average Commute
34 min
San Francisco
24 min
St. Louis
10 min longer in San Francisco
Unemployment Rate
3.8%
San Francisco
4.3%
St. Louis
San Francisco lower
Metro Population
4.7M
San Francisco
2.8M
St. Louis
San Francisco is 1.7x larger

Beyond costs, quality of life matters. The average commute in San Francisco is 34 minutes versus 24 minutes in St. Louis, a difference of 10 minutes each way. San Francisco's lower unemployment rate of 3.8% versus 4.3% suggests a stronger job market. San Francisco skews slightly older with a median age of 38.3 vs 36.6 in St. Louis.

Other Cost of Living Comparisons

New York vs San FranciscoCOL 187 vs 214Los Angeles vs San FranciscoCOL 173 vs 214Chicago vs San FranciscoCOL 114 vs 214New York vs St. LouisCOL 187 vs 86Los Angeles vs St. LouisCOL 173 vs 86Chicago vs St. LouisCOL 114 vs 86

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Frequently Asked Questions

Is San Francisco or St. Louis more expensive?

San Francisco is 59.8% more expensive than St. Louis overall. San Francisco has a cost of living index of 214 compared to 86 for St. Louis (national average = 100). The biggest difference is housing: the median home costs $1,350,000 in San Francisco vs $205,000 in St. Louis.

How much more does housing cost in San Francisco vs St. Louis?

The median home price in San Francisco is $1,350,000, which is $1,145,000 more than St. Louis's median of $205,000. Monthly rent follows a similar pattern: $3,498/month in San Francisco vs $900/month in St. Louis, a difference of $2,598/month or $31,176/year.

What salary do I need in St. Louis to match my San Francisco income?

To maintain the same standard of living, a $131,000 salary in San Francisco is equivalent to $52,645 in St. Louis. This is based on the cost of living index ratio: San Francisco's COL index of 214 vs St. Louis's 86. Conversely, $61,400 in St. Louis equals $152,786 in San Francisco.

Which city has lower taxes, San Francisco or St. Louis?

On a median household income, the combined federal, state, and FICA tax burden is $38,738 (29.6% effective rate) in San Francisco vs $11,941 (19.4% effective rate) in St. Louis. Property taxes on the median home are $8,505/year in San Francisco (0.6% rate) vs $2,050/year in St. Louis (1.0% rate). Sales tax rates are 7.2% in California and 4.2% in Missouri.

What is the median household income in San Francisco and St. Louis?

San Francisco median household income: $131,000/yr. St. Louis median household income: $61,400/yr (Census ACS).

How does rent compare in San Francisco vs St. Louis?

Median monthly rent: $3,498 in San Francisco vs $900 in St. Louis. Annualized that is $41,976 vs $10,800.

Which city is better for remote workers, San Francisco or St. Louis?

St. Louis offers a lower cost of living (index 86 vs 214), which lets remote-workers keeping a coastal salary stretch further. San Francisco typically wins on amenities and labor-market depth.

Where does the data on this comparison come from?

San Francisco and St. Louis numbers are pulled from Zillow ZHVI/ZORI (home values, rent), the U.S. Census Bureau ACS (income, demographics), and BEA RPP (cost-of-living index). Each value is timestamped on the page.

How often is this San Francisco vs St. Louis comparison updated?

Source feeds (Zillow, Freddie Mac PMMS, Census ACS, BEA RPP) are refreshed on their native cadence. Page caches revalidate every 24 hours via Next.js ISR.

Does this comparison replace tax or financial advice?

No. The San Francisco vs St. Louis cost-of-living page is educational reference using public data and standard formulas. It is not personalized tax, legal, or investment advice. Consult a licensed professional for material decisions.

Explore More

All City ComparisonsSan Francisco COL CalculatorSt. Louis COL CalculatorSalary GuidesMortgage Affordability CalculatorRent vs Buy Calculator

Sources & Citations

  1. Zillow Research — ZHVI (home values) & ZORI (observed rent index) — zillow.com/research/data
  2. U.S. Census Bureau — American Community Survey (ACS) 5-year estimates — census.gov/acs
  3. Bureau of Economic Analysis — Regional Price Parities by state and MSA — bea.gov/rpp
  4. Tax Foundation — effective state and local tax rates — taxfoundation.org
  5. Freddie Mac PMMS — weekly national average mortgage rates — freddiemac.com/pmms
  6. Internal Revenue Service — federal income tax brackets and standard deduction — irs.gov
  7. U.S. Bureau of Labor Statistics — unemployment and wage statistics — bls.gov
Methodology & Assumptions

Home prices use Zillow Home Value Index (ZHVI)[1]; rents use Zillow Observed Rent Index (ZORI)[1]. Median household income comes from the Census ACS 5-year estimates[2].

COL indices use the BEA Regional Price Parity methodology[3], normalized so 100 = national average.

Property tax rates are effective rates from the Tax Foundation[4], expressed as % of owner-occupied home value. Mortgage estimates assume 6.5% fixed rate[5], 30-year term, 20.0% down, $1,800/yr homeowners insurance.

Federal tax calculations[6] assume single filer, standard deduction. State tax uses the top marginal rate times taxable income after the state standard deduction. FICA = 6.2% Social Security (up to wage base) + 1.45% Medicare.

Salary equivalence uses adjusted = salary × (COL_destination / COL_origin). This captures cost-of-living shift but not state income tax differences.

Unemployment figures are the most recent monthly MSA-level readings from the BLS LAUS series[7].

Last reviewed is computed from the maximum retrievedAt across every source this page consumes.

City data from Census Bureau[2], BLS[7], and Zillow[1] (2024-2025). Tax calculations use 2025 IRS rates[6], single filer, standard deduction. Mortgage estimates assume 6.5% PMMS rate[5], 30-year term, 20.0% down. COL Index: 100 = national average[3]. Last reviewed 2026-04-19.